Degree of adherence to recommended antiviral treatment during the pandemic and post-pandemic periods of influenza A(H1N1)pdm09 in 148 intensive care units in Spain.
Identifieur interne : 000188 ( Main/Exploration ); précédent : 000187; suivant : 000189Degree of adherence to recommended antiviral treatment during the pandemic and post-pandemic periods of influenza A(H1N1)pdm09 in 148 intensive care units in Spain.
Auteurs : L. Canadell [Espagne] ; I. Martín-Loeches [Espagne] ; E. Díaz [Espagne] ; S. Trefler [Espagne] ; S. Grau [Espagne] ; J C Yebenes [Espagne] ; J. Almirall [Espagne] ; M. Olona [Espagne] ; F. Sureda [Espagne] ; J. Blanquer [Espagne] ; A. Rodriguez [Espagne]Source :
- Medicina intensiva [ 1578-6749 ] ; 2015.
Descripteurs français
- KwdFr :
- Adhésion au traitement médicamenteux (statistiques et données numériques), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Comorbidité (MeSH), Complications infectieuses de la grossesse (épidémiologie), Durée du séjour (statistiques et données numériques), Enregistrements (MeSH), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (traitement médicamenteux), Grippe humaine (épidémiologie), Grossesse (MeSH), Guides de bonnes pratiques cliniques comme sujet (MeSH), Humains (MeSH), Indice APACHE (MeSH), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Oséltamivir (usage thérapeutique), Pandémies (MeSH), Soins de réanimation (statistiques et données numériques), Sous-type H1N1 du virus de la grippe A (MeSH), Sujet âgé (MeSH), Taux de survie (MeSH), Tumeurs hématologiques (épidémiologie), Unités de soins intensifs (statistiques et données numériques), Utilisation médicament (statistiques et données numériques), Études de cohortes (MeSH).
- MESH :
- statistiques et données numériques : Adhésion au traitement médicamenteux, Durée du séjour, Soins de réanimation, Unités de soins intensifs, Utilisation médicament.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antiviraux, Oséltamivir.
- épidémiologie : Complications infectieuses de la grossesse, Espagne, Grippe humaine, Tumeurs hématologiques.
- Adulte, Adulte d'âge moyen, Comorbidité, Enregistrements, Femelle, Grossesse, Guides de bonnes pratiques cliniques comme sujet, Humains, Indice APACHE, Modèles des risques proportionnels, Mâle, Pandémies, Sous-type H1N1 du virus de la grippe A, Sujet âgé, Taux de survie, Études de cohortes.
English descriptors
- KwdEn :
- APACHE (MeSH), Adult (MeSH), Aged (MeSH), Antiviral Agents (therapeutic use), Cohort Studies (MeSH), Comorbidity (MeSH), Critical Care (statistics & numerical data), Drug Utilization (statistics & numerical data), Female (MeSH), Hematologic Neoplasms (epidemiology), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Intensive Care Units (statistics & numerical data), Length of Stay (statistics & numerical data), Male (MeSH), Medication Adherence (statistics & numerical data), Middle Aged (MeSH), Oseltamivir (therapeutic use), Pandemics (MeSH), Practice Guidelines as Topic (MeSH), Pregnancy (MeSH), Pregnancy Complications, Infectious (epidemiology), Proportional Hazards Models (MeSH), Registries (MeSH), Spain (epidemiology), Survival Rate (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- drug therapy : Influenza, Human.
- epidemiology : Hematologic Neoplasms, Influenza, Human, Pregnancy Complications, Infectious, Spain.
- statistics & numerical data : Critical Care, Drug Utilization, Intensive Care Units, Length of Stay, Medication Adherence.
- APACHE, Adult, Aged, Cohort Studies, Comorbidity, Female, Humans, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Pandemics, Practice Guidelines as Topic, Pregnancy, Proportional Hazards Models, Registries, Survival Rate.
Abstract
OBJECTIVE
To determine the degree of antiviral treatment recommendations adherence and its impact to critical ill patients affected by influenza A(H1N1)pdm09 mortality.
DESIGN
Secondary analysis of prospective study.
SETTING
Intensive care (UCI).
PATIENTS
Patients with influenza A(H1N1)pdm09 in the 2009 pandemic and 2010-11 post-Pandemic periods.
VARIABLES
Adherence to recommendations was classified as: Total (AT); partial in doses (PD); partial in time (PT), and non-adherence (NA). Viral pneumonia, obesity and mechanical ventilation were considered severity criteria for the administration of high antiviral dose. The analysis was performed using t-test or «chi» square. Survival analysis was performed and adjusted by Cox regression analysis.
RESULTS
A total of 1,058 patients, 661 (62.5%) included in the pandemic and 397 (37.5%) in post-pandemic period respectively. Global adherence was achieved in 41.6% (43.9% and 38.0%; P=.07 respectively). Severity criteria were similar in both periods (68.5% vs. 62.8%; P=.06). The AT was 54.7% in pandemic and 36.4% in post-pandemic period respectively (P<.01). The NA (19.7% vs. 11.3%; P<.05) and PT (20.8% vs. 9.9%, P<.01) was more frequent in the post-pandemic period. The mortality rate was higher in the post-pandemic period (30% vs. 21.8%, P<.001). APACHE II (HR=1.09) and hematologic disease (HR=2.2) were associated with a higher mortality and adherence (HR=0.47) was a protective factor.
CONCLUSIONS
A low degree of adherence to the antiviral treatment was observed in both periods. Adherence to antiviral treatment recommendations was associated with lower mortality rates and should be recommended in critically ill patients with suspected influenza A(H1N1)pdm09.
DOI: 10.1016/j.medin.2014.06.001
PubMed: 25107582
Affiliations:
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Martín-Loeches</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Corporación Sanitaria Parc Taulí, CIBERES, Sabadell, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Corporación Sanitaria Parc Taulí, CIBERES, Sabadell</wicri:regionArea><wicri:noRegion>Sabadell</wicri:noRegion></affiliation></author><author><name sortKey="Diaz, E" sort="Diaz, E" uniqKey="Diaz E" first="E" last="Díaz">E. Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Corporación Sanitaria Parc Taulí, CIBERES, Sabadell, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Corporación Sanitaria Parc Taulí, CIBERES, Sabadell</wicri:regionArea><wicri:noRegion>Sabadell</wicri:noRegion></affiliation></author><author><name sortKey="Trefler, S" sort="Trefler, S" uniqKey="Trefler S" first="S" last="Trefler">S. Trefler</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Grau, S" sort="Grau, S" uniqKey="Grau S" first="S" last="Grau">S. Grau</name><affiliation wicri:level="4"><nlm:affiliation>Servicio de Farmacia Hospitalaria, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Farmacia Hospitalaria, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Yebenes, J C" sort="Yebenes, J C" uniqKey="Yebenes J" first="J C" last="Yebenes">J C Yebenes</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Mataró, Mataró, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Hospital Universitario de Mataró, Mataró</wicri:regionArea><wicri:noRegion>Mataró</wicri:noRegion></affiliation></author><author><name sortKey="Almirall, J" sort="Almirall, J" uniqKey="Almirall J" first="J" last="Almirall">J. Almirall</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Mataró, Mataró, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Hospital Universitario de Mataró, Mataró</wicri:regionArea><wicri:noRegion>Mataró</wicri:noRegion></affiliation></author><author><name sortKey="Olona, M" sort="Olona, M" uniqKey="Olona M" first="M" last="Olona">M. Olona</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Preventiva - Hospital Universitario de Tarragona Joan XXIII, Tarragona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Preventiva - Hospital Universitario de Tarragona Joan XXIII, Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Sureda, F" sort="Sureda, F" uniqKey="Sureda F" first="F" last="Sureda">F. Sureda</name><affiliation wicri:level="1"><nlm:affiliation>Cátedra de Farmacología clínica - Universidad Rovira i Virgili, Tarragona, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cátedra de Farmacología clínica - Universidad Rovira i Virgili, Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author><author><name sortKey="Blanquer, J" sort="Blanquer, J" uniqKey="Blanquer J" first="J" last="Blanquer">J. Blanquer</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Hospital Clínico, Valencia, España.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Hospital Clínico, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A" last="Rodriguez">A. Rodriguez</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona, España; Centros de Investigación Biomédica en Red Enfermedades Respiratorias , Tarragona, España. Electronic address: ahr1161@yahoo.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona, España; Centros de Investigación Biomédica en Red Enfermedades Respiratorias , Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author></analytic><series><title level="j">Medicina intensiva</title><idno type="eISSN">1578-6749</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APACHE (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antiviral Agents (therapeutic use)</term><term>Cohort Studies (MeSH)</term><term>Comorbidity (MeSH)</term><term>Critical Care (statistics & numerical data)</term><term>Drug Utilization (statistics & numerical data)</term><term>Female (MeSH)</term><term>Hematologic Neoplasms (epidemiology)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (drug therapy)</term><term>Influenza, Human (epidemiology)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Length of Stay (statistics & numerical data)</term><term>Male (MeSH)</term><term>Medication Adherence (statistics & numerical data)</term><term>Middle Aged (MeSH)</term><term>Oseltamivir (therapeutic use)</term><term>Pandemics (MeSH)</term><term>Practice Guidelines as Topic (MeSH)</term><term>Pregnancy (MeSH)</term><term>Pregnancy Complications, Infectious (epidemiology)</term><term>Proportional Hazards Models (MeSH)</term><term>Registries (MeSH)</term><term>Spain (epidemiology)</term><term>Survival Rate (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adhésion au traitement médicamenteux (statistiques et données numériques)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antiviraux (usage thérapeutique)</term><term>Comorbidité (MeSH)</term><term>Complications infectieuses de la grossesse (épidémiologie)</term><term>Durée du séjour (statistiques et données numériques)</term><term>Enregistrements (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (traitement médicamenteux)</term><term>Grippe humaine (épidémiologie)</term><term>Grossesse (MeSH)</term><term>Guides de bonnes pratiques cliniques comme sujet (MeSH)</term><term>Humains (MeSH)</term><term>Indice APACHE (MeSH)</term><term>Modèles des risques proportionnels (MeSH)</term><term>Mâle (MeSH)</term><term>Oséltamivir (usage thérapeutique)</term><term>Pandémies (MeSH)</term><term>Soins de réanimation (statistiques et données numériques)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Taux de survie (MeSH)</term><term>Tumeurs hématologiques (épidémiologie)</term><term>Unités de soins intensifs (statistiques et données numériques)</term><term>Utilisation médicament (statistiques et données numériques)</term><term>Études de cohortes (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hematologic Neoplasms</term><term>Influenza, Human</term><term>Pregnancy Complications, Infectious</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Critical Care</term><term>Drug Utilization</term><term>Intensive Care Units</term><term>Length of Stay</term><term>Medication Adherence</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Adhésion au traitement médicamenteux</term><term>Durée du séjour</term><term>Soins de réanimation</term><term>Unités de soins intensifs</term><term>Utilisation médicament</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications infectieuses de la grossesse</term><term>Espagne</term><term>Grippe humaine</term><term>Tumeurs hématologiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>APACHE</term><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Practice Guidelines as Topic</term><term>Pregnancy</term><term>Proportional Hazards Models</term><term>Registries</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Enregistrements</term><term>Femelle</term><term>Grossesse</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Indice APACHE</term><term>Modèles des risques proportionnels</term><term>Mâle</term><term>Pandémies</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sujet âgé</term><term>Taux de survie</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To determine the degree of antiviral treatment recommendations adherence and its impact to critical ill patients affected by influenza A(H1N1)pdm09 mortality.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Secondary analysis of prospective study.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Intensive care (UCI).</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS</b></p><p>Patients with influenza A(H1N1)pdm09 in the 2009 pandemic and 2010-11 post-Pandemic periods.</p></div><div type="abstract" xml:lang="en"><p><b>VARIABLES</b></p><p>Adherence to recommendations was classified as: Total (AT); partial in doses (PD); partial in time (PT), and non-adherence (NA). Viral pneumonia, obesity and mechanical ventilation were considered severity criteria for the administration of high antiviral dose. The analysis was performed using t-test or «chi» square. Survival analysis was performed and adjusted by Cox regression analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 1,058 patients, 661 (62.5%) included in the pandemic and 397 (37.5%) in post-pandemic period respectively. Global adherence was achieved in 41.6% (43.9% and 38.0%; P=.07 respectively). Severity criteria were similar in both periods (68.5% vs. 62.8%; P=.06). The AT was 54.7% in pandemic and 36.4% in post-pandemic period respectively (P<.01). The NA (19.7% vs. 11.3%; P<.05) and PT (20.8% vs. 9.9%, P<.01) was more frequent in the post-pandemic period. The mortality rate was higher in the post-pandemic period (30% vs. 21.8%, P<.001). APACHE II (HR=1.09) and hematologic disease (HR=2.2) were associated with a higher mortality and adherence (HR=0.47) was a protective factor.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>A low degree of adherence to the antiviral treatment was observed in both periods. Adherence to antiviral treatment recommendations was associated with lower mortality rates and should be recommended in critically ill patients with suspected influenza A(H1N1)pdm09.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25107582</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>20</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1578-6749</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>4</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Medicina intensiva</Title><ISOAbbreviation>Med Intensiva</ISOAbbreviation></Journal><ArticleTitle>Degree of adherence to recommended antiviral treatment during the pandemic and post-pandemic periods of influenza A(H1N1)pdm09 in 148 intensive care units in Spain.</ArticleTitle><Pagination><MedlinePgn>222-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.medin.2014.06.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0210-5691(14)00143-0</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the degree of antiviral treatment recommendations adherence and its impact to critical ill patients affected by influenza A(H1N1)pdm09 mortality.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Secondary analysis of prospective study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Intensive care (UCI).</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">Patients with influenza A(H1N1)pdm09 in the 2009 pandemic and 2010-11 post-Pandemic periods.</AbstractText><AbstractText Label="VARIABLES" NlmCategory="METHODS">Adherence to recommendations was classified as: Total (AT); partial in doses (PD); partial in time (PT), and non-adherence (NA). Viral pneumonia, obesity and mechanical ventilation were considered severity criteria for the administration of high antiviral dose. The analysis was performed using t-test or «chi» square. Survival analysis was performed and adjusted by Cox regression analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 1,058 patients, 661 (62.5%) included in the pandemic and 397 (37.5%) in post-pandemic period respectively. Global adherence was achieved in 41.6% (43.9% and 38.0%; P=.07 respectively). Severity criteria were similar in both periods (68.5% vs. 62.8%; P=.06). The AT was 54.7% in pandemic and 36.4% in post-pandemic period respectively (P<.01). The NA (19.7% vs. 11.3%; P<.05) and PT (20.8% vs. 9.9%, P<.01) was more frequent in the post-pandemic period. The mortality rate was higher in the post-pandemic period (30% vs. 21.8%, P<.001). APACHE II (HR=1.09) and hematologic disease (HR=2.2) were associated with a higher mortality and adherence (HR=0.47) was a protective factor.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A low degree of adherence to the antiviral treatment was observed in both periods. Adherence to antiviral treatment recommendations was associated with lower mortality rates and should be recommended in critically ill patients with suspected influenza A(H1N1)pdm09.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Canadell</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Servicio de Farmacia Hospitalaria, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín-Loeches</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Corporación Sanitaria Parc Taulí, CIBERES, Sabadell, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Díaz</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Corporación Sanitaria Parc Taulí, CIBERES, Sabadell, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trefler</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grau</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Servicio de Farmacia Hospitalaria, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yebenes</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Mataró, Mataró, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almirall</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Mataró, Mataró, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olona</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Preventiva - Hospital Universitario de Tarragona Joan XXIII, Tarragona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sureda</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Cátedra de Farmacología clínica - Universidad Rovira i Virgili, Tarragona, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanquer</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Hospital Clínico, Valencia, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Intensiva, Hospital Universitario de Tarragona Joan XXIII, Universitat Rovira i Virgili, Institut d'Investigaciò Sanitaria Pere Virgili, Tarragona, España; Centros de Investigación Biomédica en Red Enfermedades Respiratorias , Tarragona, España. Electronic address: ahr1161@yahoo.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>GETGAG</CollectiveName></Author></AuthorList><Language>eng</Language><Language>spa</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Spain</Country><MedlineTA>Med Intensiva</MedlineTA><NlmUniqueID>9207689</NlmUniqueID><ISSNLinking>0210-5691</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018806" MajorTopicYN="N">APACHE</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003422" MajorTopicYN="N">Critical Care</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004363" MajorTopicYN="N">Drug Utilization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019337" MajorTopicYN="N">Hematologic Neoplasms</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055118" MajorTopicYN="N">Medication Adherence</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017410" MajorTopicYN="N">Practice Guidelines as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Adherence</Keyword><Keyword MajorTopicYN="Y">Adherencia</Keyword><Keyword MajorTopicYN="Y">Antiviral treatment</Keyword><Keyword MajorTopicYN="Y">Gripe A (H1N1)pdm09</Keyword><Keyword MajorTopicYN="Y">Influenza A(H1N1)pdm09</Keyword><Keyword MajorTopicYN="Y">Prognosis</Keyword><Keyword MajorTopicYN="Y">Pronóstico</Keyword><Keyword MajorTopicYN="Y">Tratamiento antivírico</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Cobo</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martins</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carbayo</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robles-Musso</LastName><ForeName>Emilio</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cárdenas</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fierro</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Ocaña</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sierra</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Huertos</LastName><ForeName>M Jesús</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pozo</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guerrero</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Márquez</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez-Carvajal</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jiménez</LastName><ForeName>Juan Ramón</ForeName><Initials>JR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jareño</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pomares</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ballesteros</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Yolanda</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lobato</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prieto</LastName><ForeName>José F</ForeName><Initials>JF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albofedo-Sánchez</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Castellanos</LastName><ForeName>Miguel Ángel Díaz</ForeName><Initials>MÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sevilla</LastName><ForeName>Guillermo</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Garnacho-Montero</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hinojosa</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Esteban</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Loza</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>León</LastName><ForeName>Cristóbal</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arenzana</LastName><ForeName>Ángel</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ocaña</LastName><ForeName>Dolores</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navarrete</LastName><ForeName>Inés</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Avellanas</LastName><ForeName>Manuel Luis</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lander</LastName><ForeName>Arantxa</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Arellano</LastName><ForeName>S Garrido Ramírez</ForeName><Initials>S</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>González</LastName><ForeName>Carmen Pascual</ForeName><Initials>CP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Quiroga</LastName></Investigator><Investigator ValidYN="Y"><LastName>García-Rodríguez</LastName><ForeName>Águeda</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Socias</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ibánez</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Borges-Sa</LastName><ForeName>Marcío</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Socias</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>del Castillo</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marcos</LastName><ForeName>Ricard 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ValidYN="Y"><LastName>Regalado</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lorente</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martín</LastName><ForeName>Mar</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cáceres</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Suberviola</LastName><ForeName>Borja</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ugarte</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>García-López</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alonso</LastName><ForeName>Ángel Álvaro</ForeName><Initials>ÁÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pasilla</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grande</LastName><ForeName>M Luisa Gómez</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albaya</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Canabal</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marina</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Messa</LastName><ForeName>Juan B López</ForeName><Initials>JB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pueyo</LastName><ForeName>M Jesús López</ForeName><Initials>M</Initials></Investigator><Investigator 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